Airports:

GSP (Greenville-Spartanburg, SC) CLT (Charlotte-Douglas, NC)

Hotel Suggestions:

Downtown Greenville Area- There are over 100 restaurants on "main" street. Great area to be in as a visitor to the area. This is a new hotel just off main street.

https://www.marriott.com/hotels/travel/gspgr-residence-inn-greenville-downtown/

Woodruff Road- Safe bet for most hotels that have an address on this road. (Tip: Read trip advisor reviews)